General Information

  • ID:  hor001949
  • Uniprot ID:  O42143
  • Protein name:  Glucagon-like peptide 1A
  • Gene name:  gcg1
  • Organism:  Xenopus laevis (African clawed frog)
  • Family:  Glucagon family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Xenopus (subgenus), Xenopus (genus), Xenopodinae (subfamily), Pipidae (family), Pipoidea (superfamily), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0007165 signal transduction; GO:0050896 response to stimulus
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HAEGTFTSDVTQQLDEKAAKEFIDWLINGGPSKEIIS
  • Length:  37(97-133)
  • Propeptide:  MKSTCYMIGILLMILQNTYQSPVPETDANSRSVKAARNEAVDDSEQLKEVKRHSQGTFTSDYSKYLDSRRAQDFVQWLMNTKRSGELSRRNADYERHAEGTFTSDVTQQLDEKAAKEFIDWLINGGPSKEIISRRNAEFERHAEGTYTNDVTEYLEEKAAKEFIEWLIKGKPKKIRYSRHAEGTFTNDMTNYLEEKAAKEFVGWLIKGRPKRNFSEVHSVEEMDRRHADGSFTNDINKVLDIIAAQEFLDWVINT
  • Signal peptide:  MKSTCYMIGILLMILQNTYQ
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Promotes hydrolysis of glycogen and lipids, and raises the blood sugar level.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  AF-O42143-F1(AlphaFold_DB_ID)

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor001949_AF2.pdbhor001949_ESM.pdb

Physical Information

Mass: 471881 Formula: C181H280N46O61
Absent amino acids: CMRY Common amino acids: EI
pI: 4.19 Basic residues: 4
Polar residues: 10 Hydrophobic residues: 13
Hydrophobicity: -46.76 Boman Index: -6024
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 79.19
Instability Index: 2466.22 Extinction Coefficient cystines: 5500
Absorbance 280nm: 152.78

Literature

  • PubMed ID:  NA
  • Title:  NA